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MicroRNAs as key regulators of cancer drug resistance: insights and future directions in chemotherapy, targeted-therapy, radiotherapy, and immunotherapy
Open Access Review 10 Dec 2025
DOI:
10.20517/cdr.2025.146
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Unraveling resistance to immune checkpoint inhibitors in HNSCC: from mechanisms to combination therapies
Open Access Review 5 Dec 2025
DOI:
10.20517/cdr.2025.153
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Disrupting resistance: novel therapeutic approaches to combat multidrug resistance in fusion-negative rhabdomyosarcoma
Open Access Review 3 Dec 2025
DOI:
10.20517/cdr.2025.145
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Osimertinib acquired resistance among patients with EGFR-mutated NSCLC: from molecular mechanisms to clinical therapeutic strategies
Open Access Review 2 Dec 2025
DOI:
10.20517/cdr.2025.140
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Overcoming cancer drug resistance through small-molecule targeting of HSP90 and HSP70
Open Access Review 1 Dec 2025
DOI:
10.20517/cdr.2025.149
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Mechanisms of resistance to antibody-drug conjugates in cancer therapy: molecular basis and therapeutic strategies
Open Access Review 28 Nov 2025
DOI:
10.20517/cdr.2025.148
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RCC1 knockdown sensitizes drug-resistant colorectal cancer to 5-fluorouracil or doxorubicin by impairing DNA repair
Open Access Original Article 10 Nov 2025
DOI:
10.20517/cdr.2025.159
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Novel FAK inhibitors suppress tumor growth and reverse EGFR-TKI resistance in non-small cell lung cancer
Open Access Original Article 5 Nov 2025
DOI:
10.20517/cdr.2025.139
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Circular RNA-based liquid biopsy: a promising approach for monitoring drug resistance in cancer
Open Access Review 30 Oct 2025
DOI:
10.20517/cdr.2025.142
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Targeting tumor-draining lymph node to overcome resistance to cancer immunotherapy: an update
Open Access Review 24 Oct 2025
DOI:
10.20517/cdr.2025.126
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Recent progress on tyrosine kinase inhibitors resistance in renal cell carcinoma: another brick in the wall?
Open Access Review 15 Oct 2025
DOI:
10.20517/cdr.2025.157
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KLF5 promotes tumor proliferation and oxaliplatin resistance via chromatin remodeling in KRAS-mutated colorectal cancer
Open Access Original Article 10 Oct 2025
DOI:
10.20517/cdr.2025.110
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CDK4/6 and BET inhibitors synergistically suppress pancreatic tumor growth and epithelial-to-mesenchymal transition by regulating the GSK3β-mediated Wnt/β-catenin pathway
Open Access Original Article 26 Sep 2025
DOI:
10.20517/cdr.2025.38
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Cisplatin resistance in head and neck squamous cell carcinoma is linked to DNA damage response and cell cycle arrest transcriptomics rather than poor drug uptake
Open Access Original Article 19 Sep 2025
DOI:
10.20517/cdr.2025.107
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Molecular targeting of the deubiquitinase USP14 to circumvent cisplatin resistance in ovarian carcinoma and identification of novel inhibitors
Open Access Original Article 18 Sep 2025
DOI:
10.20517/cdr.2025.88
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Distinct adaptive strategies to cisplatin, vinblastine and gemcitabine in a panel of chemoresistant bladder cancer cell lines
Open Access Original Article 12 Sep 2025
DOI:
10.20517/cdr.2025.95
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Immune checkpoint inhibitors in hepatocellular carcinoma therapy: resistance mechanisms, liver transplantation challenges and management strategies
Open Access Review 11 Sep 2025
DOI:
10.20517/cdr.2025.120
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Integrating genomic mutations and tumor-infiltrating lymphocytes improves prediction of response to trastuzumab-based adjuvant therapy in patients with HER2-positive breast cancer
Open Access Original Article 8 Sep 2025
DOI:
10.20517/cdr.2025.133
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